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HMO reference material




General HMO bioactivity and bioavalibility



Oligosaccharides from human milk induce growth arrest via G2/M by influencing growth-related cell cycle genes in intestinal epithelial cells.
S. Kuntz, C. Kunz, S. Rudloff  British Journal of Nutrition 2009 101(9), 1306-1315
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=5542420




Antiinfective Properties of Human Milk.
G. Chirico, R. Marzollo, S. Cortinovis, C. Fonte, A. Gasparoni The Journal of Nutrition 2008, 138,1801S-1806S
http://jn.nutrition.org/cgi/content/abstract/138/9/1801S





Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism.
A. Caspi, B. Williams, J. Kim-Choen, I. W. Craig, B. J. Milne, R. Poulton, L. C. Schalkwyk, A. Taylor, H. Werts, T. E. Moffitt PNAS, 2007, 104(47), 18860-18865
http://www.ncbi.nlm.nih.gov/pubmed/17984066





Protection of the Neonate by the Innate Immune System of Developing Gut and of Human Milk
D. S. Newburg, W. A. Walker Pediatric Research 2007, 61(1), 2-8
http://journals.lww.com/pedresearch/Fulltext/2007/01000/ Protection_of_the_Neonate_by_the_Innate_Immune.3.aspx





Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis
G.Der, G. D. Batty, I. J. Deary British Medical Journal 2006, 333, 945
http://www.bmj.com/cgi/content/abstract/bmj.38978.699583.55v1





Human Milk Oligosaccharides Inhibit the Adhesion to Caco-2 Cells of Diarrheal Pathogens: Eschericha coli, Vibrio cholera, and Salmonella fyris
G. V. Coppa, L. Zampini, T. Galeazzi, B. Facinelli, L. Ferrante, R. Capretti, G. Orazio Pediatric Research 2006, 59(3), 377-382
http://journals.lww.com/pedresearch/Fulltext/2006/03000/Human_Milk_Oligosaccharides_Inhibit_the_Adhesion.7.aspx





Carbohydrates as future anti-adhesion drugs for infectious diseases
N. Sharon Biochimica et Biophysica Acta  2006, 1760, 527-537
http://cat.inist.fr/?aModele=afficheN&cpsidt=17703473





Resent Advances on Structure, Metabolism, and Function of Human Milk Oligosaccharides
L. Bode The Journal of Nutrition 2006, 136, 2127-2130
http://jn.nutrition.org/cgi/content/abstract/136/8/2127





Human and Bovine Milk Oligosaccharides Inhibit
Neisseria meningitides Pili Attachment In Vitro J. Hakkarainen, M. Toivanen, A. Leinonen, L. Frängsmyr, N. Strömberg, S. Lapinjoki, X. Nassif, C. Tikkanen-Kaukanen The Journal of Nutrition 2005, 135, 2445-2448
http://jn.nutrition.org/cgi/content/abstract/135/10/2445





Human Milk Glycans Protect Infants Against Enteric Pathogens
D. S. Newburg, G. M. Ruiz-Palacios, A. L. Morrow Annual Review of  Nutrition 2005, 25, 37-58
http://www.ncbi.nlm.nih.gov/pubmed/16011458





Breast-Feeding Influences Cognitive Development in Filipino Children
M. C. Daniels, L. S. Adir The Journal of Nutrition 2005, 135, 2589-2295
http://jn.nutrition.org/





Prebiotics in infant formulas
G. Boehm, J. Jelinek, B. Sthal, K. van Laere, J. Knol, S. Fanaro, G. Moro, V. Vigi Journal of Clinical Gastroenterology 2004, 38(6 Suppl), S76-79
http://www.ncbi.nlm.nih.gov/pubmed/15220664





Oligosaccharides: application in infant food
M. Rivero-Urgell, A. Santamaria-Orleans Early Human Development 2001, 65 Suppl., S43-S52
http://linkinghub.elsevier.com/retrieve/pii/S037837820100202X





Oligosaccharides in Human Milk: Structural, Functional, and Metabolic Aspects
C. Kunz, S. Rudloff, W. Baier, N. Klein, S. Strobel Annual Review of  Nutrition 2000, 20, 699-722
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.nutr.20.1.699





The First Prebiotics in Humans, Human Milk Oligosaccharides
G. V. Coppa, S. Bruni, L. Morelli, S. Soldi, O. Gabrielli Journal of  Clinical Gastroenterology 2004, 38(2), S80-S83
http://journals.lww.com/jcge/Abstract/2004/07002/The_First_Prebiotics_in_Humans__Human_Milk.8.aspx





Health promoting aspects of milk oligosaccharides
C. Kunz, S. Rudloff International Dairy Journal 2006, 1341-1346
http://cat.inist.fr/?aModele=afficheN&cpsidt=18197984





Human milk oligosaccharides affect P-selectin binding capacities: in vitro investigation
G. Schumacher, G. Bendas, B. Sthal, C. Beermann Nutrition 2006, 22(6), 620-627
http://linkinghub.elsevier.com/retrieve/pii/S0899900706000244





Human Milk Glycans Protect Infants Against Enteric Pathogens
A. L. Morrow, G. M. Ruiz-Palacios, D. S. Newburg Annual Review of  Nutrition 2005, 25: 37-58
http://www.ncbi.nlm.nih.gov/pubmed/16011458





Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea
A. L. Morrow, G. M. Ruiz-Palacios, X. Jiang, D. S. Newburg Journal of Nutrition 2005, 135(5), 1304-1307
http://jn.nutrition.org/cgi/content/full/135/5/1304





Human milk provides peptides highly stimulating the growth of bifidobacteria
C. Liepke, K. Adermann, M. Raida, H.-J. Mägert, W.-G. Forssmann, H.-D. Zucht European Journal of Biochemistry 2002, 269, 712-718
http://www3.interscience.wiley.com/journal/118906564/abstract





Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract
M. B. Engfer, B. Stahl, B. Finke, G. Sawatzki, H. Daniel The American Journal of Clinical Nutrition 2000, 71, 1589-1596
http://www.ajcn.org/cgi/content/abstract/71/6/1589





&Human milk oligosaccharides: 130 reasons to breast-feed
J. C. Brand Miller, P. McVeagh British Journal of Nutrition 1999, 82, 333-335
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=885832&fulltextType=AC&fileId=S0007114599001567





Immune Protection of Human Milk
M. Xanthou Biology of Neonate 1998, 74, 121-133
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=14018&Ausgabe=225275&ProduktNr=224215





Early and Late Effects of Breast-Feeding: Does Breast-Feeding Really Matter?
S. Villalpando, M. Hamosh Biology of the Neonate 1998, 74, 177-191
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=14022&Ausgabe=225275&ProduktNr=224215




2’-Fucosyllactose




Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells
S. Kuntz, S. Rudloff, C. Kunz British Journal of Nutrition 2008, 99(3), 462-471
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1700580&fulltextType=RA&fileId=S0007114507824068





Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
A. L. Morrow, G. M. Ruiz-Palacios, M. Altaye, X. Jiang, M. Lourdes Guerrero, J. K. Meinzen-Derr, T. Farkas, P. Chaturvedi, L. K. Pickering, D. S. Newburg Journal of Pediatrics 2004, 145(3), 297-303
http://www.jpeds.com/article/S0022-3476(04)00375-0/abstract





Immunomodulation of fucosyl-lactose and lacto-N-fucopentaose on mononuclear cells from multiple sclerosis and healthy subjects
S. Sotgiu, G. Arru, M. L. Fois, A. Sanna, M. Musumeci, G. Rosati, S. Musumeci International Journal of Biomedical Science 2006, 2(2), 114-120
http://ijbs.org/User/ContentAbstractPage.aspx?VolumeNO=2&StartPage=114&EndPage=120&Number=2





Innate protection conferred by fucosylated oligosaccharides of human against diarrhea in breastfed infants
D.S. Newburg, G. M. Ruiz-Palacios, M. Altaye, P. Chaturvedi, J. Meinzen-Derr, M. de L. Guerrero, A. L. Morrow Glycobiology 2004, 14(3), 253-263
http://glycob.oxfordjournals.org/cgi/content/abstract/14/3/253





Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation
P. Chaturvedi, C. D. Warren, M. Altaye, A. L. Morrow, G. Ruiz-Palacios, L. K. Pickering, D. S. Newburg Glycobiology 2001, 11(5), 365-372
http://glycob.oxfordjournals.org/cgi/content/full/11/5/365




LNnT




The Schistosome Oligosaccharide Lacto-N-neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naïve CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth Infections
L. I. Terrazas, K. L. Walsh, D. Piskorska, E. McGuire, D. A. Harn, Jr. The Journal of  Immunology 2001, 167, 5294-5303
http://www.jimmunol.org/cgi/content/abstract/167/9/5294





Sialylation of Neisseria meningitides Lipooligosaccharide Inhibits Serum Bactericidal Activity by Masking Lacto-N-Neotetraose
M. M. Estabrook, J. McLeod Griffiss, G. A. Jarvis Infection and Immunity 1997, 65(11), 4436-4444
http://iai.asm.org/cgi/content/abstract/65/11/4436




LNT




Effects of Holder pasteurization on human milk oligosaccharides
E. Bertoni, G. V. Coppa, F. Giuliani, A. Coscia, O. Gabrielli, G. Sabatino, M. Sgarrella, T. Testa, L. Zampini, C. Fabris Int. J. Immunopathology and Pharmacology 2008, 21(2) 381-385
http://www.ncbi.nlm.nih.gov/pubmed/18547467





Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells
S. Kuntz, S. Rudloff, C. Kunz British Journal of Nutrition 2008, 99(3), 462-471
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1700580&fulltextType=RA&fileId=S0007114507824068





Glycoprofiling of Bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation
R. G. LoCascio, M. R. Ninonuevo, S. L. Freeman, D. A. Sela, R. Grimm, C. B. Lebrilla, D. A. Mills, J. B. German Journal of  Agricultural and Food Chemistry 2007, 55(22), 8914-8919
http://www.ncbi.nlm.nih.gov/pubmed/17915960





Human milk oligosaccharides: A novel method provides insight into human genetics
R. Emey, M. Hilty, L. Pickering, G. Ruiz-Palacios, P. Prieto Advances in Experimental Medicine and Biology 2001, 501(Bioactive Components of Human Milk), 285-297
http://www.ncbi.nlm.nih.gov/pubmed/11787692




6’-Sialyllactose and 3-Sialyllactose




Sialic acid residues play a pivotal role in α1-acid glycoprotein (AGP)-induced generation of reactive oxygen species in chemotactic peptide pre-activated neutrophil granulocytes
P. Gunnarsson, L. Fornander, P. Påhlsson, M. Grenegård Inflammation Research 2010, 59, 89-95
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:292219





Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells
S. Kuntz, S. Rudloff, C. Kunz British Journal of Nutrition 2008, 99, 462-471
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1700580&fulltextType=RA&fileId=S0007114507824068





Monitoring of influenza virus hemagglutinin in process samples using weak affinity ligands and surface Plasmon resonance
C.-F. Mandenius, R. Wang, A. Aldén, G. Bergström, S. Thébault, C. Lutsch, S. Ohlson Analytica Chimica Acta 2008, 623, 66-75
http://www.ncbi.nlm.nih.gov/pubmed/18611459





Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation
S. Asakuma, M. Akahori, K. Kimura, Y. Watanabe, T. Nakamura, M. Tadashi, I. Arai, Y. Sanai, T. Urashima Bioscience Biotechnology and Biochemistry 2007, 71(6), 1447-1451
http://www.jstage.jst.go.jp/article/bbb/71/6/71_1447/_article





Dietary sialic acid supplementation improves learning and memory in piglets
B. Wang, B. Yu, M. Karim, H. Hu, Y. Sun, P. Mcgreevy, P. Petocz, S. Held, J. Brand-Miller American Journal of Clinical Nutrition 2007, 85, 561-569
http://www.ajcn.org/cgi/content/abstract/85/2/561





Inhibitition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides
L. Bode, C. Kunz, M. Muhly-Reinholz, K. Meyer, W. Seeger, S. Rudloff Thrombosis and Haemostasis 2004, 92(6), 1402-1410
http://journals.indexcopernicus.com/abstracted.php?icid=497210





Human milk-derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro
T. Eiwegger, B. Stahl, J. Schmitt, G. Boehm, M. Gerstmayr, J. Pichler, E. Dehlink, C. Loibichler, R. Urbanek, Z. Szepflausi Pediatric Research 2004, 56(4), 536-540
http://journals.lww.com/pedresearch/Fulltext/2004/10000/Human_Milk_Derived_Oligosaccharides_and.4.aspx





Brain ganglioside and glycoprotein sialic acid in breastfed compared with formula-fed infants
B. Wang, P. McVeagh, P. Petocz, J. Brand-Miller American Journal of Clinical Nutrition 2003, 78(5), 1024-1029
http://www.ajcn.org/cgi/content/abstract/78/5/1024





The role and potential of sialic acid in human nutrition
B. Wang, J. Brand-Miller European Journal of Clinical Nutrition 2003, 57(11) 1351-1369
http://www.nature.com/ejcn/journal/v57/n11/abs/1601704a.html





The Sialylated Fraction of Milk Oligosaccharides Is Partially Responsible for Binding to Enterotoxigenic and Uropathogenic Escherichia coli Human Strains
S. Martín-Sosa, M.-J. Martín, P. Hueso The Journal of Nutrition 2002, 132, 3067-3072
http://jn.nutrition.org/cgi/content/abstract/132/10/3067





Concentration and distribution of sialic acid in human milk and infant formulas
B. Wang, J. Brand-Miller, P. McVeagh, P. Petocz American Journal of Clinical Nutrition 2001, 74(4), 510-515
http://www.ajcn.org/cgi/content/abstract/74/4/510




3-Fucosyllactose




Oligosaccharides Structurally Related to E-Selectin Ligands Are Inhibitors of Neural Cell Division: Synthesis, Conformational Analysis, and Biological Activity
J. M. Corterón, K. Singh, J. L. Asensio, M. Domínguez-Dalda, A. Fernández-Mayoralas, J. Jiménez-Barbero, M. Martín-Lomas Journal of Organic Chemistry 1995, 60(6), 1502-1519
http://pubs.acs.org/doi/abs/10.1021/jo00111a008




L-Fucose




L-Fucose: occurrence, physiological role, chemical, enzymatic and micobial synthesis
P. T. Vanhooren, E. J. Vandamme Journal of  Chemcal Technology and Biotechnology 1999, 74, 479-497
http://cat.inist.fr/?aModele=afficheN&cpsidt=1805963





Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying á-l-fucose moieties
K. Yuan, D. Kucik, R. K. Singh, C. M. Listinsky, J. J. Listinsky, G. P. Siegal International  Journal of  Oncology. 2008, 32(4), 797-807
http://citation.nstl.gov.cn/detail.jsp?internal_id=766577





Cell surface associated á-l-fucose moities modulate human breast cancer neoplastic progression
K. Yuan, C. M. Listinsky, R. K. Singh, J. J. Listinsky, G. P. Siegal Pathology & Oncology Research 2008, 14(2), 145-156
http://www.springerlink.com/content/k01251x4300447w8/





Characterization and role of fucose mutarotase in mammalian cells
D. Park, K.-S. Ryu, D. Choi, J. Kwak, C. Park Glycobiology 2007, 17(9), 955-962
http://glycob.oxfordjournals.org/cgi/content/full/17/9/955





Age-Related Alterations in the Carbohydrate Residue Composition of the Cell Surface in the Unexposed Normal Human Epidermis
S. Georgiou, E. Pasmatzi, A. Monastirli, T. Sakkis, S. Alachioti, D. Tsambaos Gerontology 2005, 51(3), 155-160
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=83986&Ausgabe=230771&ProduktNr=224091





M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy
F. Roth-Walter, I. Schoell, E. Untersmayr, R. Fuchs, G. Boltz-Nitulescu, A. Weissenboeck, O. Scheiner, F. Gabor, E. Jensen-Jarolim Journal of  Allergy and Clinical Immonology 2004, 114(6) 1362-1368
http://cat.inist.fr/?aModele=afficheN&cpsidt=16333118





Prediction of 3-D structures of fucose-binding and structural analysis of their interaction with ligands
S. Majumder, A. Roy, C. Mandal Glycoconjugate Journal 2004, 20(9), 545-550
http://cat.inist.fr/?aModele=afficheN&cpsidt=16255877





Cutting Edge: Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells
B. J. Appelmelk, I. van Die, S. J. van Vliet, C. M. J. E.  Vandenbrouke-Graules, T. B. H. Geijtenbeek, Y. van Kooyk The Journal of Immunology 2003, 170(4), 1635-1639
http://www.jimmunol.org/cgi/content/abstract/170/4/1635





Fucose: biosynthesis and biological function in mammals
D. J. Becker, J. B. Lowe Glycobiology 2003, 13(7), 41R-53R
http://glycob.oxfordjournals.org/cgi/content/abstract/13/7/41R





Immunoreactivity in mammals of two typical plant glycol-epitopes, core á(1,3)-fucose and core xylose
M. Bardor, C. Faveeuw, A.-C. Fitchette, D. Gilbert, L. Galas, F. Trottein, L. Faye, P. Lerouge Glycobiology 2003, 13(6), 427-434
http://glycob.oxfordjournals.org/cgi/content/abstract/13/6/427





A novel fucose recognition fold involved in innate immunity
M. A. Bianchet, E. W. Odom, G. R. Vasta, M. L. Amzel Nature Structural Biology 2002, 9(8), 628-634
http://www.nature.com/nsmb/journal/v9/n8/full/nsb817.html